Liquid Crystals as Novel Vesicular Delivery System: a Review
نویسنده
چکیده
Recently, liquid crystals (LCs) studied as novel drug delivery system. The reason for this interest is due to the extensive similarity of these colloidal systems to those in living organism and their superior advantageous properties over traditional dermal, parenteral and oral dosage forms. LCs show structural, mechanical, and optical properties intermediate to those of crystalline solids and isotropic liquids. There are two principal types of LCs. Lyotropic liquid crystals (LLCs) and thermotropic liquid crystals (TLCs). LLCs are prepared by heating the anisotropic substances in presence of solvent while TLCs are prepared by heating the anisotropic substances or cooling an isotropic melt of TLCs forming substances. LCs are thermodynamically stable and they possess longer shelf life. The utility of this novel system is further increased owing to its very low skin irritation potential. This review covers introduction, classification, characterization and applications of
منابع مشابه
P107: Using Nano Particles as a Novel Application for Alzheimer’s Disease; an Effective Endeavor for Drug Delivery
As the most common cause of dementia among the elderly results in cognitive and ‎behavioral impairment, Alzheimer’s disease (AD) is characterized with aggregation of senile ‎plaques (Beta-amyloid protein), cortical atrophy and ventricular enlargement. Unfortunately, ‎conventional methods like acetyl cholinesterase inhibitor drugs, are not so effective owing to ‎restrictive...
متن کاملA Review of Vesicular and Polymeric Nano-systems in Olanzapine Drug Delivery
Olanzapine (2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno [2, 3-b][1, 5]benzodiazepine) is an antipsychotic drug with poor water-solubility that has a suitable affinity to some receptors. This benzodiazepine derivative is a new (atypical) antipsychotic drug and has a wide range of efficacy, especially in treatment of patients with negative psychiatric symptoms of schizophrenia. Olanzapine is ...
متن کاملVesicular System-Carrier for Drug Delivery
The application of vesicular system in drug delivery has changed the definitions of diagnosis and treatment in different aspects of biomedical field. The vesicular system as liposomes, niosomes, sphinosomes, transferosomes and pharmacosomes are used to improve the therapeutic index of both existing and new drug molecules by encapsulating an active medicament inside vesicular structure in one su...
متن کاملVesicular Systems: An Overview
There has been keen interest in the development of a novel drug delivery system. Novel drug delivery system aims to deliver the drug at a rate directed by the needs of the body during the period of treatment, and channel the active entity to the site of action. At present, no available drug delivery system behaves ideally achieving all the lofty goals, but sincere attempts have been made to ach...
متن کاملSynthesis and Characterization of Novel Modified and Functionalized Silica Nano-particles for Protein Delivery Applications
In this study, the synthesis, characterization and controlled release behavior of new Hollow Silica Nano particles (HSNPs) and Magnetic Silica Nano Particles (MSNPs) were studied. Magnetic Silica Nano particles (MSNPs), as drug delivery vehicles, were synthesized through the coating of Fe3O4 nano-crystals with silica layers. The HSNPs were obtained by removal of Fe3O4 templates with hydrochlori...
متن کامل